Antiviral innate immunity pathways

SnapShot: Pathways of Antiviral Innate Immunity

Mitochondria and antiviral innate immunity.

Mitochondria, dynamic organelles that undergo continuous cycles of fusion and fission, are the powerhouses of eukaryotic cells. Recent research indicates that mitochondria also act as platforms for antiviral immunity in vertebrates. Mitochondrial-mediated antiviral immunity depends on activation of the retinoic acid-inducible gene I (RIG-I)-like receptors signal transduction pathway and the par...

Sensing and Signaling in Antiviral Innate Immunity

Viruses are detected by the innate immune system, leading to the initiation of the anti-viral immune response via the production of type I interferons and inflammatory cytokines such as interleukin-1. Remarkable progress has been made over the past few years towards understanding the contribution of Toll-like receptors, RIG-I like receptors, NOD-like receptors and HIN-200 family members to vira...

MAVS Coordination of Antiviral Innate Immunity.

RNA virus infection is sensed in the cytoplasm by the retinoic acid-inducible gene I (RIG-I)-like receptors. These proteins signal through the host adaptor protein MAVS to trigger the antiviral innate immune response. Here, we describe how MAVS subcellular localization impacts its function and the regulation underlying MAVS signaling. We propose a model to describe how the coordination of MAVS ...

Innate immunity: cells, receptors, and signaling pathways.

Essential differences between the innate and acquired branches of immunity are described. These differences concern the detection system (receptors and pathogen structures) and the cells engaged in both systems as well as the effectory mechanisms. In contrast to those of the acquired system, receptors of the innate system, which developed during evolution, recognize unchanged structures on larg...